Pot Treats Cancer Without The Devastating Effects of Chemotherapy

Research shows THC and other compounds found only in marijuana don't just soothe symptoms; they can shrink tumors and slow the spread of cancer. 
By Martin A. Lee

Smoke Signals: A Social History of Marijuana -- Medical, Recreational, and Scientific [2] (Simon and Schuster, 2012):

Peer-reviewed scientific studies in several countries show THC and other compounds found only in marijuana are effective not only for cancer symptom management (pain, nausea, loss of appetite, fatigue, and so on), but they confer a direct antitumoral effect as well.

Animal experiments conducted by Manuel Guzmán at Madrid’s Complutense University in the late 1990s revealed that a synthetic cannabinoid injected directly into a malignant brain tumor could eradicate it. Reported in Nature Medicine, this remarkable finding prompted additional studies in Spain and elsewhere that confirmed the anticancer properties of marijuana-derived compounds. Guzmán’s team administered pure THC via a catheter into the tumors of nine hospitalized patients with glioblastoma (an aggressive form of brain cancer) who had failed to respond to standard therapies. This was the first clinical trial assessing the antitumoral action of cannabinoids on human beings, and the results, published in the British Journal of Cancer, were very promising. THC treatment was associated with significantly reduced tumor cell proliferation in all test subjects.

Guzmán and his colleagues found that THC and its synthetic emulators selectively killed tumor cells while leaving healthy cells unscathed. No Big Pharma chemotherapy drugs could induce apoptosis (cell death) in cancer cells without trashing the whole body. Up to 90 percent of advanced cancer patients suffer cognitive dysfunction from “chemo brain,” a common side effect of corporate cancer meds that indiscriminately destroy brain matter, whereas cannabinoids are free-radical scavengers that protect brain tissue and stimulate brain cell growth.

There is mounting evidence that cannabinoids may “represent a new class of anticancer drugs that retard cancer growth, inhibit angiogenesis [the formation of new blood vessels] and the metastatic spreading of cancer cells,” according to the scientific journal Mini-Reviews in Medicinal Chemistry. Studies from scientists around the world have documented the anticancer properties of cannabinoid compounds for various malignancies, including (but not limited to):

• Prostate cancer. Researchers at the University of Wisconsin found that the administration of the synthetic cannabinoid WIN-55,212–2, a CB-1and CB-2 agonist, inhibited prostate cancer cell growth and also induced apoptosis.
• Colon cancer. British researchers demonstrated that THC triggers cell death in tumors of the colon, the second leading cause of cancer deaths in the United States.
• Pancreatic cancer. Spanish and French scientists determined that cannabinoids selectively increased apoptosis in pancreatic cell lines and reduced the growth of tumor cells in animals, while ignoring normal cells.
• Breast cancer. Scientists at the Pacific Medical Centers in San Francisco found that THC and other plant cannabinoids inhibited human breast cancer cell proliferation and metastasis and shrank breast cancer tumors. 1.3 million women worldwide are diagnosed yearly with breast cancer and a half million succumb to the disease.
• Cervical cancer. German researchers at the University of Rostock reported that THC and a synthetic cannabinoid suppressed the invasion of human cervical carcinoma into surrounding tissues by stimulating the body’s production of TIMP-1, a substance that helps healthy cells resist cancer.
• Leukemia. Investigators at St. George’s University and Bartholomew’s Hospital in London found that THC acts synergistically with conventional antileukemia therapies to enhance the effectiveness of anti-cancer agents in vitro (in a test tube or petri dish). Scientists had previously shown that THC and cannabidiol were both potent inducers of apoptosis in leukemic cell lines.
• Stomach cancer. According to Korean researchers at the Catholic Uni- versity in Seoul, WIN-55,212–2, the synthetic cannabinoid, reduced the proliferation of stomach cancer cells.
• Skin carcinoma. Spanish researchers noted that the administration of synthetic cannabinoids “induced a considerable growth inhibition of malignant tumors” on the skin of mice.
• Cancer of the bile duct. The administration of THC inhibits bile-duct cancer cell proliferation, migration, and invasion and induces biliary cancer cell apoptosis, according to experiments conducted at Rangsit University in Patum Thani, Thailand.
• Lymphoma, Hodgkin’s and Kaposi’s sarcoma. Researchers at the University of South Florida ascertained that THC thwarts the activation and replication of the gamma herpes virus. This virus increases a person’s chances of developing cancers such as Hodgkin’s, non-Hodgkin’s lymphoma, and Kaposi’s sarcoma.
• Liver cancer. Italian scientists at the University of Palermo found that a synthetic cannabinoid caused programmed cell death in liver cancer.
• Lung cancer. Harvard University scientists reported that THC cuts tumor growth in common lung cancer in half and “significantly reduces the ability of the cancer to spread.” Lung cancer is the number one cancer killer in the world. More Americans die of lung cancer each year than any other type of cancer.

Existing Drug Becomes Cheap Cancer Cure In Canada

University of Alberta scientists do understand the cause of cancer. The dying off of old cells to be replaced by new cells is a normal part of our cellular life-cycle and keeps us well. It seems that in cancerous cells, our body has forgotten how to tell the aged cells how to die off and be replaced by healthy new cells.

This process is governed by the mitochondria and is known as "cell death" or "apoptosis". In a cancer cell, the mitochondria has lost the ability to direct the cell to die off - the sick cell becomes "immortal", spreading and making the person increasingly unwell.

Trials using  dichloroacetate (DCA) have proven this compound can reactivate the mitochondria restoring the cell's original function of "apoptosis" enabling shrinkage in tumor size and mass. Testimonials have shown reversal in illness, remission, clean health tests, increased health and vitality. Favourable results (scientifically measurable) have been accomplished within days (less than a week) of starting treatment with DCA.

"Dr. Evangelos Michelakis, a professor at the University of Alberta Department of Medicine, has shown that DCA causes regression in several cancers, including lung, breast, and brain tumors."

It sounds too good to be true: a cheap and simple drug that kills almost all cancers by switching off their immortality. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.

DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar.

Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakiss experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died (Cancer Cell).

Michelakis suggests that the switch to glycolysis as an energy source occurs when cells in the middle of an abnormal but benign lump dont get enough oxygen for their mitochondria to work properly (see diagram). In order to survive, they switch off their mitochondria and start producing energy through glycolysis.

Crucially, though, mitochondria do another job in cells: they activate apoptosis, the process by which abnormal cells self-destruct. When cells switch mitochondria off, they become immortal, outliving other cells in the tumour and so becoming dominant. Once reawakened by DCA, mitochondria reactivate apoptosis and order the abnormal cells to die.

The results are intriguing because they point to a critical role that mitochondria play:  they impart a unique trait to cancer cells that can be exploited for cancer therapy, says Dario Altieri, director of the University of Massachusetts Cancer Center in Worcester.

The phenomenon might also explain how secondary cancers form. Glycolysis generates lactic acid, which can break down the collagen matrix holding cells together. This means abnormal cells can be released and float to other parts of the body, where they seed new tumours.

DCA can cause pain, numbness and gait disturbances in some patients, but this may be a price worth paying if it turns out to be effective against all cancers. The next step is to run clinical trials of DCA in people with cancer. These may have to be funded by charities, universities and governments: pharmaceutical companies are unlikely to pay because they cant make money on unpatented medicines. The pay-off is that if DCA does work, it will be easy to manufacture and dirt cheap.